Table 1 In vitro α-glucosidase inhibitory activities of benzo[d]imidazole-amide-1,2,3-triazole-N-arylacetamide hybrids 8a–n.

From: Design, synthesis, in vitro, and in silico evaluations of benzo[d]imidazole-amide-1,2,3-triazole-N-arylacetamide hybrids as new antidiabetic agents targeting α-glucosidase

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Compound

R

IC50 (µM)a

8a

H

> 750

8b

2-Methyl

> 750

8c

3-Methyl

49.0 ± 0.4

8d

4-Methyl

> 750

8e

2,3-Dimethyl

119.2 ± 0.8

8f.

2,4-Dimethyl

422.6 ± 1.1

8g

2,6-Dimethyl

125.6 ± 0.3

8h

4-Ethyl

251.9 ± 1.6

8i

4-Methoxy

> 750

8j

4-F

> 750

8k

4-Cl

134.2 ± 0.9

8l

2,4-Dichloro

668.5 ± 1.4

8m

4-Br

183.6 ± 0.8

8n

4-Nitro

> 750

Acarbose

–

750.0 ± 2.0

  1. aData are expressed as mean ± S.E. of at least three different experiments.
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