Table 3 Druglikeness/ADME/T profile of acarbose and the most potent compound 8c.

From: Design, synthesis, in vitro, and in silico evaluations of benzo[d]imidazole-amide-1,2,3-triazole-N-arylacetamide hybrids as new antidiabetic agents targeting α-glucosidase

Druglikeness/ADME/Ta

Compound

Acarbose

8c

Rule of Five

Violated

Suitable

Caco2

9.44448

1.37022

HIA

0.000000

87.699415

BBB

0.0271005

0.104802

Skin permeability

− 5.17615

− 4.62683

Carcino mouse

Positive

Negative

Carcino rat

Negative

Negative

  1. aThe recommended ranges for CaCO2: < 25 poor, > 500 great, HIA: > 80% is high < 25% is poor, BBB = − 3.0 to 1.2, and Skin_Permeability = − 8.0 to − 1.0.
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