Figure 3

Humanized mice transduced with hACE2 AdV support SARS-CoV-2 infection. (A) Schematic illustration showing generation and infection of humanized hACE2 NIKO mouse model with WT or ∆382 viruses. Measurement of body weight (B) and virus titre (C) in uninfected (UI) controls, WT and ∆382 infected humanized hACE2 NIKO mice. Data representative of 2 independent in vivo experiments. Data are represented as mean ± SEM. Two-tailed Mann–Whitney U test; (*p < 0.05, **p < 0.01, ***p < 0.001).