Figure 5

Analysis of cytokine and chemokine responses in infected humanized mice. Human-specific cytokine and chemokine release of IL-1β, IFN-α, IFN-γ, TNF-α, MCP-1 (CCL2), IL-6, IL-8 (CXCL8), IL-10, IL-12p70, IL-17A, IL-18, IL-23, and IL-33 were measured in the plasma of humanized mice administered with WT, ∆382 and UI controls at day 3 (D3), day 5 (D5) and day 7 (D7). Data representative of 2 independent in vivo experiments. Data are represented as mean ± SEM. Two-tailed Mann–Whitney U test; (*p < 0.05, **p < 0.01, ***p < 0.001).