Table 1 Effect of SM of halophilic and halotolerant bacterial strains on the viability of normal and tumor cells.

From: A phenol amine molecule from Salinivenus iranica acts as the inhibitor of cancer stem cells in breast cancer cell lines

Cell lines strain

HFF-5

PC3

LNCaP

DU145

A549

MDA-MB-468

MCF-7

MDA-MB-231

Salinivenus iranica

800 µg/mL

400 µg/mL

200 µg/mL

400 µg/mL

400 µg/mL

100 µg/mL

100 µg/mL

100 µg/mL

IBRC M 10036

36.75 ± 1.39

55.87 ± 0.48

52.62 ± 2.51

57.9 ± 0.41

58.92 ± 1.05

50.71 ± 2.32

50.97 ± 3.24

50.97 ± 3.24

MGM 23%

Salinibacter ruber

400 µg/mL

200 µg/mL

100 µg/mL

200 µg/mL

200 µg/mL

100 µg/mL

100 µg/mL

100 µg/mL

IBRC M 10423

51.85 ± 2.54

59.22 ± 2.55

50.49 ± 2.45

45.72 ± 4.12

55.83 ± 2.54

53.40 ± 2.42

58.14 ± 1.52

50.97 ± 3.24

MGM 23%

Salinivenus lutea

200 µg/mL

400 µg/mL

200 µg/mL

800 µg/m

400 µg/mL

200 µg/mL

400 µg/mL

NT

IBRC M 10423

50.15 ± 0.81

55.27 ± 5/01

51.80 ± 1.14

42.68 ± 1.51

58.04 ± 3.31

44.14 ± 2.00

34.35 ± 2.70

MGM 23%

Aquibacillus albus

800 µg/mL

800 µg/mL

800 µg/mL

800 µg/mL

800 µg/mL

200 µg/mL

400 µg/mL

NT

IBRC M 10798

17.06 ± 3.68

16.07 ± 0.13

33.87 ± 3.03

19.42 ± 2.08

53.01 ± 4.46

28.72 ± 0.13

23.84 ± 1.79

SWN 7%

Aliicoccus persicus

800 µg/mL

800 µg/mL

800 µg/mL

800 µg/mL

800 µg/mL

200 µg/mL

800 µg/mL

NT

IBRC M 10081

59.9 ± 6.95

27.46 ± 6.78

36.02 ± 1.51

33.19 ± 1.22

50.81 ± 4.10

50.36 ± 4.97

21.38 ± 1.23

SWN 7%

Marinobacter persicus

800 µg/mL

800 µg/mL

800 µg/mL

800 µg/mL

–

200 µg/mL

400 µg/mL

NT

IBRC M 10445

49.09 ± 4.49

38.80 ± 4.59

53.06 ± 2.54

50.56 ± 0.20

41.74 ± 5.24

45.87 ± 1.48

SWN 3%

Ornithinibacillus halophilus

–

800 µg/mL

200 µg/mL

800 µg/mL

–

400 µg/mL

400 µg/mL

NT

IBRC M 10683

13.76 ± 0.20

44.42 ± 2.73

46.60 ± 1.40

40.00 ± 1.30

47.27 ± 0.43

SWN 3%

Bacillus halosaccharovorans

–

–

800 µg/mL

–

–

400 µg/mL

800 µg/mL

NT

IBRC M 10095

44.90 ± 1.34

50.31 ± 0.12

45.02 ± 2.29

SWN 3%

Alteribacillus bidgolensis

–

–

–

–

–

400 µg/mL

800 µg/mL

NT

IBRC M 10614

48.30 ± 4.27

40.12 ± 3.73

SWN 7%

Salinithrix halophila

–

800 µg/mL

800 µg/mL

–

–

–

–

NT

IBRC M 10813

49.45 ± 1.50

46.72 ± 3.71

SWN 3%

Bacillus salsus

–

–

–

–

100 µg/mL

–

–

NT

IBRC M 10078

53.97 ± 11.4

SWN 3%

Aquibacillus halophilus

–

–

–

–

–

800 µg/mL

–

NT

IBRC M 10775

26.58 ± 0.48

SWN 7%

Aquibacillus korensis

–

–

–

–

–

800 µg/mL

–

NT

IBRC M 10657

31.12 ± 1.08

SWN 7%

Halobacillus karajensis

–

–

–

–

–

800 µg/mL

–

NT

IBRC M 10221

39.20 ± 0.23

SWN 3%

Lentibacillus persicus

–

–

–

–

–

400 µg/mL

–

NT

IBRC M 10440

51.20 ± 0.19

SWN 3%

Piscibacillus halophilus

–

–

–

–

–

800 µg/mL

–

NT

IBRC M 10220

45.46 ± 2.83

SWN 7%

Saliterribacillus persicus

–

–

–

–

–

800 µg/mL

–

NT

IBRC M 10629

37.90 ± 2.42

SWN 3%

Salinispirillum marinum

–

–

800 µg/mL

–

–

–

–

NT

IBRC M 10765

38.79 ± 0.85

SWN 3%

Alloactinosynnema iranicum

–

–

–

–

–

–

–

NT

IBRC M 10403

ISPII 0.5%

Alteribacillus persepolensis

–

–

–

–

–

–

–

NT

IBRC M 10436

SWN 7%

Bacillus iranensis

–

–

–

–

–

–

–

NT

IBRC M 10446

SWN 3%

Bacillus persicus

–

–

–

–

–

–

–

NT

IBRC M 10115

SWN 3%

Cyclobacterium halophilum

–

–

–

–

–

–

–

NT

IBRC M 10761

SWN 3%

Limimonas halophila

–

–

–

–

–

–

–

NT

IBRC M 10018

MGM 23%

Oceanobacillus limi

–

–

–

–

–

–

–

NT

IBRC M 10780

SWN 3%

Pseudomonas salegens

–

–

–

–

–

–

–

NT

IBRC M 10762

SWN 3%

Salinicoccus iranensis

–

–

–

–

–

–

–

NT

IBRC M 10198

SWN 7%

Salinivibrio proteolyticus

–

–

–

–

–

–

–

NT

IBRC M 10218

SWN 3%

Thalassobacillus cyri

–

–

–

–

–

–

–

NT

IBRC M 10743

SWN 3%

  1. The numbers are referred as ≤ IC50. -: The SM did not reduce the viability of cells to ~ 50% in any of examined concentrations. Fibroblast (HFF-5), prostate cancer (PC3, LNCaP, and DU145), lung cancer (A549), and breast cancer (MDA-MB-468, MDA-MB-231 and MCF-7) cell lines. SWN Sea Water Nutrient Medium, MGM Modified Growth Medium, ISPII Yeast Malt Medium, NT Not Tested.
  2. Significant values are in bold.
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