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Figure 1

From: Time-dependent inhibition of Rac1 in the VTA enhances long-term aversive memory: implications in active forgetting mechanisms

Figure 1

Post-training inhibition of Rac1 in the VTA, but not in the HP or the AMG, enhanced IA LTM at 1, 7 and 14 days after training. (a) Experimental schedule. Animals were trained (TR) and tested by step-down latency measurement at 1, 7 and 14 days. Vehicle (Veh) or the Rac1 inhibitor NSC23766 was infused immediately after training (arrow). (b)–(d) Individual data points (left panel) and line (middle panel) graphs. Infusion of NSC23766 into the VTA significantly enhanced memory at every time (b; nVeh = 12, nNSC = 11) while no effect was observed when the infusion was made into the HP (c; nVeh = nNSC = 11) or the AMG (d; nVeh = 12, nNSC = 10). Right panel. Representative schemes (left) and photographs (right) of a coronal section of the rat brain showing the aimed cannula placement and methylene blue diffusion. Data are presented as means ± SEM. *p  < 0.05 from Mann–Whitney U for each test.

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