Table 2 Basic features of the included study (1).

From: Ethnicity-specific association between TERT rs2736100 (A > C) polymorphism and lung cancer risk: a comprehensive meta-analysis

ID	Studies	Year	Country	Ethnicity	Type of LC	LC(n)	Controls(n)	Gender (male %)		Age (years)		Percentage of smokers (%)
ID	Studies	Year	Country	Ethnicity	Type of LC	LC(n)	Controls(n)	LC	Controls	LC	Controls	LC	Controls
1	Bae⁵⁸	2012	South Korea	Asian	LC	1094	1100	76.51%	76.36%	60.7 ± 9.3	60.6 ± 9.3	79.10%	66.40%
2	Brenner (Phase 1)⁵⁹	2013	Europe, North America	Caucasian	LC	4441	5194	–	–	–	–	Partial smoking	Partial smoking
3	Brenner (Phase 2)⁵⁹	2013	USA	Caucasian	LC	5699	5818	–	–	–	–	Partial smoking	Partial smoking
4	Broderick (Phase 1)⁶⁰	2009	UK	Caucasian	LC	1952	1438	59.76%	–	57 ± 6	–	Partial smoking	Partial smoking
5	Broderick (Phase 2)⁶⁰	2009	UK	Caucasian	LC	2465	3005	68.04%	49.31%	72 ± 7	61 ± 11	Partial smoking	Partial smoking
6	Chen⁵⁰	2012	China	Asian	LC	196	229	77.55%	73.36%	55.9 ± 10.3	54.6 ± 10.2	62.76%	48.03%
					LUAD	96	229
					LUSC	44	229
					SCLC	16	229
7	Cheng⁶¹	2016	China	Asian	LC	2331	3077	73.40%	67.79%	52.34%(≥ 60 )	53.56%(≥ 60)	64.05%	42.96%
8	Dong¹⁴	2017	China	Asian	NSCLC	192	278	72.90%	71.20%	46.90%(≥ 60 )	48.20%(≥ 60)	67.20%	47.50%
9	Furuie⁶²	2021	Japan	Asian	LC	462	379	62.10%	74.70%	68 (62–73)	58 (48–65)	66.90%	44.80%
10	Hosgood¹²	2015	Asia	Asian	LC	1730	1349	0%	0%	52.30%(≥ 59 )	52.8%(≥ 59)	Non-smoking	Non-smoking
11	Hsiung⁴⁵	2010	Asia	Asian	LC	2308	2321	0%	0%	56.3–63.4	56.3–64.7	Non-smoking	Non-smoking
					LUAD	1748	2321
					LUSC	177	2321
12	Hu¹⁰	2011	China	Asian	LC	8559	9378	69.05%	66.77%	59.11–60.08	56.51–62.45	58.36%	39.98%
					LUSC	3017	9378
					LUAD	4323	9378
					SCLC	780	9378
					LC Smoker	5026	3815
					LC Non smoker	3533	5563
13	Ito⁶³	2012	Japan	Asian	LC	716	716	74.16%	74.16%	–	–	75.20%	59.36%
14	Jaworowska⁶⁴	2011	Poland	Caucasian	LC	855	844	73.70%	73.70%	61 (28–88)	61 (28–88)	87.50%	49.90%
15	Jin⁶⁵	2009	China	Asian	NSCLC	1212	1339	74.40%	74.70%	48.50%(> 60)	48.10%(> 60)	64.40%	44.50%
					LUAD	711	1339
					LUSC	374	1339
					NSCLC Smoker	786	598
					NSCLC Non smoker	425	746
16	Kohno⁶⁶	2011	Japan	Asian	LUSC	370	320	90.19%	56.92%	62.7 ± 7.6	62.5 ± 11.3	97%	45%
17	Lan⁶⁷	2013	China	Asian	LC	193	197	0%	0%	58.14%(≥ 60 )	59.07%(≥ 60 )	7.44%	4.65%
18	Lan⁶⁸	2012	Asia	Asian	LC	5505	4543	0%	0%	58.8 ± 11.2	55.1 ± 13.7	Non-smoking	Non-smoking
19	Landi⁶⁹	2009	USA, Europe	Caucasian	LC	5739	5848	–	–	–	–	93.69%	76.03%
					LUAD	1730	5848
					LUSC	1400	5848
					SCLC	678	5848
					LC Smoker	5356	4425
					LC Non smoker	362	1402
20	Li⁷⁰	2012	China	Asian	LC	2283	2785	73.72%	73.21%	60.09 ± 10.29	60.56 ± 9.58	64.91%	45.53%
21	Li⁵¹	2016	China	Asian	LC	391	337	67.52%	67.66%	58.63 ± 8.8	38.8 ± 10.7	No description	No description
22	Liu⁷¹	2015	China	Asian	LC	288	317	48.36%	49.22%	59.63 ± 10.82	43.06 ± 15.02	No description	No description
23	Machiela⁷²	2015	Asia	Asian	LC	5457	4493	0%	0%	63.00%(≥ 50)	63.00%(≥ 50)	Non-smoking	Non-smoking
24	Mandour⁷³	2020	Egypt	Caucasian	LC	40	40	50%	22.50%	44.13 ± 16.18	34.45 ± 9.98	Non-smoking	Non-smoking
					NSCLC	36	40
					SCLC	2	40
					LUAD	26	40
					LUSC	4	40
25	McKay⁷⁴	2008	USA, Europe	Caucasian	LC	2971	3746	–	–	–	–	Partial smoking	Partial smoking
26	Miki⁷⁵	2010	Japan, South Korea	Asian	LUAD	2086	11,034	53.35%	68.42%	64.8–58.9	50.5–58.9	49.10%	59.47%
27	Myneni⁴⁶	2013	China	Asian	LC	352	447	50.60%	50.20%	61.10%(≥ 55)	52.40%(≥ 55)	55.10%	38.80%
28	Pande⁷⁶	2011	USA	Caucasian	LC	1681	1235	59.50%	40.50%	63.5 ± 11	57.2 ± 13.2	72.52%	58.87%
29	Seow⁷⁷	2017	Asia	Asian	LUAD	7505	7070	0%	0%	57.9–64.6	44.2–62.0	Non-smoking	Non-smoking
30	Shiraishi⁷⁸	2016	Japan	Asian	LUAD	6830	15,155	52.29%	56.30%	64.1	47.7	54.36%	50%
31	Shiraishi⁷⁹	2012	Japan	Asian	LUAD	4648	12,364	46.92%	56.54%	58.8–63.3	44.5–56.6	48.71%	48.63%
					LUAD smoker	2269	6012
					LUAD Non smoker	2368	5182
32	Truong⁸⁰	2010	North America, Asia	Asian	LC	1686	2101	50.00%	42.00%	87.00%(≥ 50)	77.00%(≥ 50)	59.62%	37.53%
					LC Smoker	982	759
					LC Non smoker	671	1264
33	Truong⁸⁰	2010	USA, Europe	Caucasian	LC	9126	11,812	58.00%	57.00%	89.00%(≥ 50)	89.00%(≥ 50)	89.47%	63.29%
					LC Smoker	8008	6855
					LC Non smoker	934	3972
34	Wang⁸¹	2014	China	Asian	NSCLC	1552	1605	60.89%	58.44%	55.6 (29–82)	52.3 (21–29)	73.20%	53.80%
					LUAD	746	1605
					LUSC	596	1605
35	Wang⁸²	2016	China	Asian	LC	500	500	61.00%	60.40%	84.00%(≥ 50)	71.90%(≥ 50)	Partial smoking	Partial smoking
36	Wang⁴⁷	2010	UK	Caucasian	LC	239	553	57.74%	18.99%	67 (26–87)	63 (21–91)	Non-smoking	Non-smoking
					SCLC	39	553
					NSCLC	200	553
					LUAD	112	553
					LUSC	48	553
37	Wei³⁹	2015	China	Asian	NSCLC	702	2520	64.29%	34.68%	56.7–58.7	60.5 ± 10.3	50.14%	19.68%
38	Xing⁸³	2016	China	Asian	NSCLC	418	410	65.80%	61.20%	70.8 ± 16.7	71.9 ± 16.1	53.90%	49.80%
39	Yang⁸⁴	2010	USA	Caucasian	LC	1735	1036	51.47%	40.25%	64.4 ± 10.3	64.5 ± 10.8	81.04%	39.77%
					LC Smoker	1406	412
					LC Non smoker	329	624
40	Yin⁸⁵	2014	China	Asian	LC	524	524	0%	0%	56.1 ± 11.9	56.8 ± 11.1	Non-smoking	Non-smoking
40	Yin⁸⁵	2014	China	Asian	LUAD	365	524	0%	0%	56.1 ± 11.9	56.8 ± 11.1	Non-smoking	Non-smoking
41	Yoo⁸⁶	2020	South Korea	Asian	LC	699	606	100%	100%	61.1 ± 8.0	60.6 ± 6.7	100%	100%
42	Yoon⁸⁷	2010	South Korea	Asian	NSCLC	1425	3011	56.28%	60.21%	57–63	56–62	51.23%	48.25%
					LUAD	1009	3011
					LUSC	346	3011
43	Zhao⁸⁸	2013	China	Asian	LC	784	782	73.30%	71.60%	62.33 ± 10.74	62.72 ± 10.71	68.50%	52.30%
					LUAD	360	782
					LUSC	253	782
					LC Smoker	537	409
					LC Non smoker	224	373

LC Lung cancer, NSCLC non-small-cell lung carcinoma, SCLC small cell lung carcinoma, LUAD Lung adenocarcinoma, LUSC Lung squamous cell carcinoma.
Data are mean ± SD, or mean (IQR),or IQR, or n, unless otherwise stated.

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Table 2 Basic features of the included study (1).

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