Table 3 Candidate drugs for EC treatment.
Repurposed drug (DrugBank ID) | Target gene(s) | Brief description |
|---|---|---|
Sapanisertib (INK-128) (DB11836) | SLC7A5, RUNX1, ENO1, LAMA4 | An investigational, oral, highly selective ATP-competitive mTOR kinase inhibitor |
PHA-793887 (DB12686) | SLC7A5, ENO1, NR2F1, COL6A3 | A novel and potent inhibitor of multiple cyclin dependent kinases (CDK) with a particular activity against CDK2, − 5, and − 7 |
Ciclopirox (DB01188) | PKM, SLC7A11, PDK1 | Broad-spectrum topical antifungal agent used to treat mild to moderate onychomycosis of fingernails and toenails |
Sulfasalazine (DB00795) | SLC7A11 | Nonsteroidal anti-inflammatory drug used to treat Crohn's disease and rheumatoid arthritis |
Cytarabine (DB00987) | RUNX1 | Pyrimidine nucleoside analogue used to treat acute non-lymphocytic leukemia, lymphocytic leukemia, and the blast phase of chronic myelocytic leukemia |
