Figure 4 | Scientific Reports

Figure 4

From: Downregulated APOD and FCGR2A correlates with immune infiltration and lipid-induced symptoms of irritable bowel syndrome

Figure 4

Selection of candidate lipid-sensitive biomarkers for IBS patients. Candidate genes were screened out by the random forest model (a) and SVM-RFE model (b). (c) Venn graph displaying 5 hub genes selected by two models. The five overlapping genes were IGKV2-29, IGKV1-12, IGKV1D-43, APOD and FCGR2A. (d) ROC analysis of each hub gene. (e) The associations of hub genes and infiltrating immune cells in the patients with IBS after lipid infusion. 22 types of immune cells were analyzed. Red blocks represent positive correlations and blue ones represent negative correlations. (f) GSEA of each hub gene in IBS patients. *p << 0.05; ** p << 0.01.

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