Table 1 Chompret criteria. In our study, we investigated patients fulfilling category A Chompret criteria resembling the “classic” LFS phenotype.

From: Challenging interpretation of germline TP53 variants based on the experience of a national comprehensive cancer centre

Category A

Proband with a core tumour before age 46 years and ≥ 1 first- or second-degree relative with a core tumour (except a breast cancer if proband had breast cancer) before age 56 years

OR

≥ 2 tumours (not multiple breast cancers), including 2 core tumours, the first of which occurred before age 46 years

Category B

ANY of the following:

Adrenocortical carcinoma, choroid plexus carcinoma, anaplastic rhabdomyosarcoma, breast cancer before age 31 years, osteosarcoma, childhood hypodiploid acute lymphoblastic leukaemia, sonic hedgehog-medulloblastoma

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