Figure 3
From: A titratable murine model of progressive emphysema using tracheal porcine pancreatic elastase
Emphysema acceleration in the titratable PPE model. (A) The fractional increase in mean linear intercept (MLI) between days zero and 21 and days 21 and 84 was not significant after PBS treatment, but (B) was significant after treatment with 0.5, (C) 2, and (D) 4 activity units of PPE. 21-day PBS treated MLI serves as reference for these calculations. (E) In comparing the absolute and (F) fractional increase of MLI between days zero and 21 and 21 and 84, there is a dose response in the absolute and relative increase in MLI. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 by Welch’s t-test for 2-group and by holm post hoc test after ANOVA for 4-group comparisons.
