Figure 5
From: A titratable murine model of progressive emphysema using tracheal porcine pancreatic elastase
Inflammatory Cells in the Tracheal PPE Model. (A) The lungs of mice treated with either PBS or (B) 2 activity units (U) of tracheal porcine pancreatic elastase were evaluated for immune cells by immunostaining for CD45 and performing quantitative image analysis. Representative, higher magnification photomicrographs are shown. (C) Tile scans of lung lobes with quantification of immune cell number normalized to tissue area revealed a 50% increase in the number of CD45-positive cells. Comparison is by Mann–Whitney U-test.
