Figure 5 | Scientific Reports

Figure 5

From: RETRACTED ARTICLE: Targeting transforming growth factor beta (TGF-β) using Pirfenidone, a potential repurposing therapeutic strategy in colorectal cancer

Figure 5

PFD effects on fibrosis, angiogenesis, and TME disposition. (a) Masson’s trichrome staining of tumor sections showed that fibrosis is reduced in PFD, 5-FU, and PFD + 5-FU treated groups compared to the control in tumor tissues of colorectal cancer (Black arrows indicate fibrotic area). (b) Comparison of tumor fibrosis percentage in all groups. The combination therapy of PFD and 5-FU showed more fibrosis reduction compared to the other treated groups. (c, d) The mRNA expression level of VEGFR1, COL1A1, and MMP9 in CT-26 and SW-480 cells when treated with 5-FU, PFD, and their combination for 72 h. * and #p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.

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