Figure 2 | Scientific Reports

Figure 2

From: Robust analysis of a novel PANoptosis-related prognostic gene signature model for hepatocellular carcinoma immune infiltration and therapeutic response

Figure 2

(A) A heatmap highlighted that a total of 18 PANRGs were differently expressed between normal and HCC samples in the TCGA-HCC cohort. Red indicates genes with a high expression level, while blue indicates the low expression level. *P < 0.05, ** P < 0.01, *** P < 0.001. (B) The correlation network showed the positive correlations among PANRGs except GSDMD (red line, positive correlation; blue line, negative correlation. The intensity of the colors represents the degree of the relevance). (C) A PPI network displayed the interconnections of the differentially expressed PANRGs, in which FADD was one of the hub genes. (D) The mutation frequency and classification of 18 differentially expressed PANRGs were explored in cBioPortal, in which GSDMD being the gene with the highest mutation rate. (E) The enriched items in gene ontology analysis showed the differentially expressed PANRGs were significantly correlated with cell death- and cytokine regulation-related pathways. Red indicates positive correlation, while blue indicates negative correlation. The intensity of the colors represents the strength of relevance. PANRGs, PANoptosis-related genes; TCGA, the Cancer Genome Atlas database; HCC, hepatocellular carcinoma; PPI, protein–protein interactions.

Back to article page