Table 2 Relative difference of metabolites between EarT2DM and LatT2DM groups.
Metabolites | ESI+/− | EarT2DM vs HeaCG1 | LatT2DM vs HeaCG2 | ||||
|---|---|---|---|---|---|---|---|
VIP | FC | P-value | VIP | FC | P-value | ||
d-Mannose |  +  | 3.07 | 2.08 |  < 0.001 | 2.98 | 2.00 |  < 0.001 |
l-Glutamate |  −  | 1.78 | 0.50 |  < 0.001 | 1.94 | 0.40 |  < 0.001 |
Choline |  +  | 3.92 | 0.62 |  < 0.001 | 4.28 | 0.60 |  < 0.001 |
1-Stearoyl-sn-glycerol |  +  | 1.76 | 1.63 |  < 0.001 | 2.15 | 1.68 |  < 0.001 |
1-Stearoyl-2-hydroxy-sn-glycero-3-phosphocholine |  +  | 6.88 | 0.62 |  < 0.001 | 6.97 | 0.59 |  < 0.001 |
Hypoxanthine |  +  | 2.74 | 0.37 |  < 0.001 | 3.24 | 0.32 |  < 0.001 |
2-Ethoxyethanol |  +  | 1.10 | 0.46 |  < 0.001 | 1.59 | 0.38 |  < 0.001 |
Taurine |  +  | 1.02 | 0.69 |  < 0.001 | 1.44 | 0.57 |  < 0.001 |
Dioctyl phthalate |  +  | 1.05 | 1.64 |  < 0.001 | 1.33 | 1.94 |  < 0.001 |
Erucamide |  +  | 2.01 | 2.43 |  < 0.001 | 1.48 | 1.63 | 0.019 |
l-Pipecolic acid |  +  | 1.04 | 1.81 |  < 0.001 | 1.04 | 1.82 |  < 0.001 |
1-Palmitoyl-sn-glycero-3-phosphocholine |  +  | 8.53 | 0.71 |  < 0.001 | 10.35 | 0.64 |  < 0.001 |
Acetylcarnitine |  +  | 2.14 | 0.73 | 0.002 | 1.99 | 0.72 |  < 0.001 |
1-Oleoyl-sn-glycero-3-phosphocholine |  +  | 2.78 | 0.78 | 0.005 | 2.50 | 0.75 |  < 0.001 |
1-Stearoyl-sn-glycerol 3-phosphocholine |  +  | 1.46 | 0.78 | 0.006 | 1.82 | 0.69 |  < 0.001 |
1-Palmitoylglycerol |  +  | 1.05 | 1.35 | 0.020 | 1.57 | 1.15 | 0.004 |
Alpha-D-Glucose |  −  | 10.92 | 2.32 |  < 0.001 | 9.83 | 2.22 |  < 0.001 |
l-Pyroglutamic acid |  −  | 3.54 | 0.41 |  < 0.001 | 3.12 | 0.39 |  < 0.001 |
d-Lyxose |  −  | 1.28 | 2.58 |  < 0.001 | 1.10 | 2.15 |  < 0.001 |
d-Quinovose |  −  | 4.53 | 0.17 |  < 0.001 | 3.46 | 0.25 |  < 0.001 |
Dulcitol |  −  | 2.99 | 0.22 |  < 0.001 | 2.26 | 0.29 |  < 0.001 |
m-Chlorohippuric acid |  −  | 2.19 | 1.50 |  < 0.001 | 1.93 | 1.41 |  < 0.001 |
9-OxoODE |  −  | 1.99 | 0.32 |  < 0.001 | 1.73 | 0.31 |  < 0.001 |
(+ −)12-HETE |  −  | 4.34 | 0.28 |  < 0.001 | 3.76 | 0.26 |  < 0.001 |
l-Gulonic gamma-lactone |  −  | 3.98 | 2.42 |  < 0.001 | 3.81 | 2.80 |  < 0.001 |
1-Oleoyl-L-.alpha.-lysophosphatidic acid |  −  | 1.65 | 0.48 |  < 0.001 | 1.55 | 0.42 |  < 0.001 |
9(S)-HODE |  −  | 1.13 | 0.44 |  < 0.001 | 1.22 | 0.30 |  < 0.001 |
13(S)-HODE |  −  | 2.30 | 0.47 |  < 0.001 | 2.16 | 0.40 |  < 0.001 |
L-Phenylalanine |  −  | 2.90 | 0.64 |  < 0.001 | 2.54 | 0.62 |  < 0.001 |
2-hydroxy-butanoic acid |  −  | 2.51 | 1.79 |  < 0.001 | 2.11 | 1.83 |  < 0.001 |
16-Hydroxypalmitic acid |  −  | 2.40 | 0.55 |  < 0.001 | 2.43 | 0.51 |  < 0.001 |
Uridine |  −  | 1.09 | 0.81 |  < 0.001 | 1.07 | 0.73 |  < 0.001 |
Norethindrone Acetate |  −  | 7.15 | 0.51 |  < 0.001 | 6.93 | 0.48 |  < 0.001 |
Myristic acid |  −  | 4.48 | 0.62 | 0.001 | 4.85 | 0.54 |  < 0.001 |
Cis-9-Palmitoleic acid |  −  | 4.10 | 0.76 | 0.001 | 2.98 | 0.77 | 0.008 |
Dodecanoic acid |  −  | 2.26 | 0.61 | 0.002 | 1.75 | 0.59 |  < 0.001 |
DL-lactate |  −  | 4.27 | 0.82 | 0.003 | 4.92 | 0.70 |  < 0.001 |
Palmitic acid |  −  | 10.78 | 0.80 | 0.003 | 12.91 | 0.75 |  < 0.001 |
Myristoleic acid |  −  | 1.90 | 0.63 | 0.004 | 2.37 | 0.52 |  < 0.001 |
All cis-(6,9,12)-Linolenic acid |  −  | 2.36 | 0.84 | 0.010 | 3.94 | 0.64 |  < 0.001 |
Nname,cis-9,10-Epoxystearic acid |  −  | 1.42 | 0.77 | 0.029 | 1.76 | 0.58 |  < 0.001 |
Ketoisocaproic acid |  −  | 8.59 | 1.32 | 0.048 | 1.24 | 1.41 | 0.019 |
1,2,3-Benzenetriol |  +  | 1.02 | 0.39 |  < 0.001 | – | – | – |
l-Leucine |  +  | 2.02 | 1.27 |  < 0.001 | – | – | – |
Betaine |  +  | 1.02 | 1.12 | 0.004 | – | – | – |
l-Carnitine |  +  | 1.49 | 0.82 | 0.006 | – | – | – |
Thioetheramide-PC |  +  | 4.49 | 1.49 | 0.023 | – | – | – |
l-Glutamine |  +  | 1.03 | 1.09 | 0.040 | – | – | – |
Dihydroxyacetone |  −  | 1.03 | 2.11 |  < 0.001 | – | – | – |
Pristanic acid |  −  | 1.19 | 0.65 |  < 0.001 | – | – | – |
Alpha-Tocopherol (Vitamin E) |  −  | 1.73 | 1.75 |  < 0.001 | – | – | – |
Cholesterol 3-sulfate |  −  | 5.25 | 1.74 |  < 0.001 | – | – | – |
2'-Deoxy-d-ribose |  −  | 4.28 | 1.55 | 0.002 | – | – | – |
Embelin |  −  | 1.23 | 0.70 | 0.013 | – | – | – |
l-Isoleucine |  −  | 2.02 | 1.24 | 0.016 | – | – | – |
Methylmalonic acid |  −  | 1.34 | 1.58 | 0.025 | 1.16 | 1.55 | 0.054 |
Deoxycholic acid |  −  | 1.79 | 1.61 | 0.032 | – | – | – |
d-Ribose |  −  | 1.30 | 1.40 | 0.058 | – | – | – |
3-Indolepropionic acid |  −  | 4.96 | 0.06 | 0.096 | – | – | – |
SOPC |  +  | 1.12 | 1.14 | 0.074 | – | – | – |
d-Proline |  +  | 1.33 | 1.14 | 0.087 | 1.60 | 1.21 | 0.008 |
3-Phenylpropanoic acid |  −  | 1.65 | 0.20 | 0.099 | 1.17 | 0.45 |  < 0.001 |
Alpha-Linolenic acid |  −  | – | – | – | 7.78 | 0.53 |  < 0.001 |
Linoleic acid |  −  | – | – | – | 19.72 | 0.67 |  < 0.001 |
Capric acid |  −  | – | – | – | 1.24 | 0.67 |  < 0.001 |
Pentadecanoic acid |  −  | – | – | – | 1.23 | 0.71 |  < 0.001 |
l-Arginine |  −  | – | – | – | 1.01 | 2.12 | 0.006 |
2E-Eicosenoic acid |  −  | – | – | – | 1.29 | 0.79 | 0.017 |
11(Z),14(Z)-Eicosadienoic acid |  −  | – | – | – | 1.40 | 0.83 | 0.025 |
Heptadecanoic acid |  −  | – | – | – | 1.21 | 0.82 | 0.026 |
