Figure 1

Differentially expressed lipid metabolism genes in AD. (A) Scatter plot of lipid metabolism DEG (log₂FC > 0.5, FDR-adjusted P-value < 0.05) by RNA-seq in N9 microglia stimulated with LPS (1 µg/ml) for 6 h versus unstimulated control cells. (B) Scatter plot of lipid metabolism DEG (log₂FC > 0.5, P < 0.05) by microarray in microglia isolated from the brains of 5XFAD mice versus wild-type mice (8 months old). For both scatter plots, up-regulated genes are shown in red and down-regulated genes are shown in green. Data are graphed as log₂FC versus − log₁₀ (P-value). (C) Venn diagram demonstrating overlap in lipid metabolism DEG between the N9 and mouse microglia datasets.