Figure 6 | Scientific Reports

Figure 6

From: Global proteomic identifies multiple cancer-related signaling pathways altered by a gut pathobiont associated with colorectal cancer

Figure 6

Working model of the oncogenic potential of SGG UCN34. Chronic colonization of host colon with SGG UCN34 induces the activation of MAPK cascades, PI3K/AKT/mTOR signaling and integrin/ILK/actin cytoskeleton pathways. SGG UCN34 alters multiple signaling pathways found downstream of EGF and FGF receptors present on colonic epithelial cells, but also downstream of PDGFA receptor present in stromal cells. SGG UCN34 induces the expansion of Pdpn+CD34+ cell in the stromal compartment, which regulates epithelial cells differentiation/proliferation. All these events contribute to pre-cancerous transformation of colon epithelium and acceleration of tumor development. Created with BioRender.com.

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