Table 4 mQTL statistics of CpGs regulated by rs394558 and rs942379 found to be unique in childhood.

From: Linkage analysis using whole exome sequencing data implicates SLC17A1, SLC17A3, TATDN2 and TMEM131L in type 1 diabetes in Kuwaiti families

SNP

SNP location

Alleles

CpG

CpG location

Beta

t stat

p-value

Functional consequences of methylation site

rs394558

3:10302172

A/G

cg17978425

3:10,289,658

 − 0.30

 − 7.19

1.40E-12

Downstream of TATDN2

rs394558

3:10302172

A/G

cg10346111

3:10,326,661

0.25

6.07

1.95E-09

Upstream of TATDN2 and GHRL, overlaps on LINC00852 and intronic region of GHRLOS

rs942379

6:25849620

A/G

cg12588279

6:26,043,732

 − 0.19

 − 5.41

8.12E-08

H2BC3/HIST1H2BB

  1. GHRL ghrelin and obestatin prepropeptide, GHRLOS ghrelin opposite strand/antisense RNA, H2BC3/HIST1H2BB H2B clustered histone 3, LINC00852 long intergenic non-protein coding RNA 852, SNP single nucleotide polymorphism, TATDN2 tatD DNase domain containing 2.
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