Table 6 Variants identified as QTL from the GTEx portal.

From: Linkage analysis using whole exome sequencing data implicates SLC17A1, SLC17A3, TATDN2 and TMEM131L in type 1 diabetes in Kuwaiti families

Linkage SNP observed in our study

Differentially regulated genes

Tissue

Normalized effect size

p-value

rs394558

IRAK2#

Adipose-subcutaneous

 − 0.27

4.80E-08

rs394558

TATDN2

Pancreas

0.31

1.60E-12

rs394558

GHRLOS

Pancreas

0.44

4.40E-12

rs394558

LINC00852

Pancreas

0.33

0.000001

rs394558

LINC00852

Testis

0.5

1.10E-11

rs942379

TRIM38#

Colon

0.4

3.40E-07

rs942379

TRIM38

Pancreas

 − 0.24

0.0000016

rs942379

SLC17A3

Testis

0.51

9.20E-12

rs942379

HIST1H2APS5

Testis

0.33

1.00E-08

rs942379

HIST1H2BA

Testis

 − 0.36

2.10E-08

rs942379

TRIM38

Testis

 − 0.1

0.00013

rs1165196

TRIM38#

Colon

0.4

1.20E-07

rs1165196

SLC17A3

Testis

0.51

8.70E-12

rs1165196

HIST1H2BA

Testis

 − 0.37

3.90E-09

rs1165196

HIST1H2APS5

Testis

0.29

7.10E-07

  1. IRAK2 Interleukin-1 receptor associated Kinase2, GHRLOS ghrelin opposite strand/antisense RNA, GTEx genotype-tissue expression, HIST1H2APS5 H2A clustered histone 5, pseudogene, HIST1H2BA H2B clustered histone 1, LINC00852 long intergenic non-protein coding RNA 852, SLC17A3 solute carrier family 17 member 3, SNP single nucleotide polymorphism, TATDN2 tatD DNase domain containing 2, TRIM38 tripartite motif containing 38.
  2. #sQTL stands for splicing quantitative trait loci. The rest of the QTL shown in the table are eQTL, expression of the quantitative trait locus.
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