Figure 2
From: Computational evidence for multi-layer crosstalk between the cadherin-11 and PDGFR pathways
(A) Cadherin 11 knockdown simulation results compared to the baseline model simulation: The dashed lines indicate where the model components were modified in the simulation setup. The steady state activity levels of PDGFR-α, cyclin-D1 and DUSP1 decreased, while the activity levels of PDGFR-β, ERK and β-catenin increased in the cadherin-11 knockdown compared to the baseline simulation. The decrease in PDGFR-α activity and the increase in PDGFR-β activity agree with the experimental results3,4. The proposed crosstalk protein, DUSP1, had decreased activity which resulted in increased ERK activity and decreased cyclin-D1 activity, which we interpreted as decreased proliferation. (B) Summary of steady state activity levels of proteins in the network under different simulation setups. We compared the steady state activity levels in the cadherin-11 knockdown for each different setup (baseline, crosstalk disabled, receptor interaction disabled, and downstream interaction disabled).
