Figure 3
From: Computational evidence for multi-layer crosstalk between the cadherin-11 and PDGFR pathways
Change in proliferation status for varying parameters influencing the proposed crosstalk. The scan was performed using the numerical values on the axes for the respective parameters, spanning a tenfold increase and decrease for each parameter, except β-catenin initial activity for which the maximum value is 1. Baseline parameter sets have been marked with an X in each plot. For each parameter set, the difference between the steady state activity level of cyclin D1 and ERK were compared. (A) β-catenin initial activity and the inhibition of DUSP1 by β-catenin, (B) activation of DUSP1 by ERK and inhibition of DUSP1 by β-catenin (C) activation of ERK by MEK and inhibition of ERK by DUSP1 and (D) activation of cyclin-D1 by DUSP1 and inhibition of ERK by DUSP1. Values > 0 indicate increased proliferation, values < 0 indicate decreased proliferation compared to the baseline parameter set because in the baseline parameter set the cyclin-D1 activity is numerically very close to the ERK activity, resulting in values close to 0 in this plot.
