Figure 3 | Scientific Reports

Figure 3

From: A computationally optimized broadly reactive hemagglutinin vaccine elicits neutralizing antibodies against influenza B viruses from both lineages

Figure 3

HAI serum antibody titers induced by wild-type B/VIC vaccinations. Immunologically naive ferrets were infected with a B/YAM virus, SH/02 (top), or with a B/VIC virus, HK/01 (bottom) and then vaccinated once 90 days later. Serum was collected at day 90 following preimmunization (Pre-Vax) and day 120 (Post-Vax). HAI titers were assessed against five B/YAM viruses (yellow) and five B/VIC viruses (purple). Values are the log2 HAI titers of each individual ferret (n = 4) from antisera collected at the two timepoints. Dotted lines indicate a 1:40 to 1:80 HAI titer range. Statistical analyses were performed using unpaired parametric t tests to determine significance of vaccine-induced antibodies: p > 0.05 = ns, p ≤ 0.05 = *, p ≤ 0.01 = **, p ≤ 0.001 = ***, p ≤ 0.0001 = ****.

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