Figure 5 | Scientific Reports

Figure 5

From: A computationally optimized broadly reactive hemagglutinin vaccine elicits neutralizing antibodies against influenza B viruses from both lineages

Figure 5

FRA neutralizing titers for Yamagata pre-immune ferrets vaccinated a single time with VLPs expressing different HA proteins: BC1, BC2, BC3, MY/04, FL/06, PH/13, CO/17, or Mock. Serum was collected at day 90 pre-vaccination (A–D) and day 120 post-vaccination (E–H) and tested against four IBVs: two from the Yamagata-lineage (A,B,E,F) and two from the Victoria-lineage (C,D,G,H). The dotted lines in the line graphs represent 50% inhibition and 80% inhibition of viral infection by antisera compared to virus-only control wells.

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