Figure 3
From: Cancer-associated fibroblasts in early-stage lung adenocarcinoma correlate with tumor aggressiveness
CAF subpopulation proportions and functions. (A) Proportion of CAF subpopulations in indolent and aggressive LUADs (indolent n = 6, aggressive n = 7, p = 0.032, outliers are highlighted by diamonds). (B) GO enrichment analysis of identified CAF subpopulations. (C) Violin plots demonstrate expression of genes associated with functions of identified CAF subpopulations. (D) Heatmap demonstrates activity of canonical signaling pathways across identified CAF subpopulations. Dendrograms are generated in accordance with hierarchical clustering. Heatmap was conducted using Python 3 (https://www.python.org). (E) Venn diagram shows intersection of differentially expressed genes in identified CAF subpopulations.
