Figure 2

MRPS6 expression is positively correlated with UPR^mt marker genes in human pancreas. (A) Human MRPS6 expression was strongly associated with the expression of UPR^mt marker genes HSPA9 (encoding mtHsp70), HSPD1 (encoding Hsp60), LONP1 (encoding LonP1), and CLPP (encoding ClpP) in specific tissues. Graphs were generated by plotting Pearson correlation efficient generated from GEPIA website using datasets from human pancreas tissues in the GETx database. R stands for Pearson correlation coefficient indicating the degree of association: “0” denotes no association and “1” denotes perfect positive association. Highlighted in red boxes are tissues (blood, brain, heart, and pancreas) with R around or higher than 0.5. (B) Correlation plots of the expression of MRPS6 and UPR^mt marker genes. (C) Correlation plots of another mitochondrial ribosome gene MRPS5 and UPR^mt marker genes.