Figure 3

Between-group differences with multivariate linear mixture models. Left-sided panels: (a-b) represent dataset 3D visualizations in the space of three significant variables (in figure (a) height, UIBC, Fe; in figure (b) height, UIBC, and satFe) with p-values for respective between-group comparisons under each panel; c shows linear dependence between height percentile and HGB evaluated with Pearson correlation coefficient (r) for subgroups of patients with non-recurrent and recurrent febrile seizures. Right-sided panels: (a-b) show distributions of regressed values for all investigated groups, c for subgroups of patients with non-recurrent and recurrent febrile seizures. Automatically enumerated discriminating thresholds are shown with dashed gray lines; corresponding SE and SP values for separation properties of control and case groups are based on model₁ (a), model₂ (b), model₃ (c). Model equations are displayed in the y-axis label descriptions. 1 healthy controls, 2 febrile patients without seizures, 3 febrile patients with non-recurrent FS, 4 febrile patients with recurrent FS, Fe serum iron concentration, satFe iron saturation, Fer serum ferritin concentration, Age age at the first febrile seizure attack, Height height percentile, FS febrile seizures, UIBC unsaturated iron-binding capacity, HGB hemoglobin, thr threshold, SE sensitivity, SP specificity, *p-values were evaluated with the Wilcoxon rank-sum test.