Table 2 Estimated coefficients in the conditional LASSO in each age group. All patients, 65–100 years; Early elderly, 65–74 years; Late elderly, 75–100 years; OR, odds ratio. (A) Number of medications and Comorbidities. (B) Concomitant medications.

Number of medications

1.1

1.161

1.095

Certain infectious and parasitic diseases

1.064

1.15

1.065

Neoplasms

0.98

0.807

–

Diseases of the blood and blood-forming organs and certain disorders, involving the immune mechanism

–

0.937

–

Endocrine, nutritional, and metabolic diseases

0.937

1.052

0.902

Mental and behavioral disorders

1.111

1.426

1.085

Nervous system diseases

1.179

1.268

1.153

Eye and adnexa diseases

1.363

1.643

1.359

Ear and mastoid process diseases

1.131

1.127

1.191

Diseases of the circulatory system

0.768

0.822

0.738

Respiratory system diseases

–

1.233

0.993

Digestive system diseases

1.193

1.379

1.177

Skin and subcutaneous tissue diseases

1.208

1.374

1.204

Musculoskeletal system and connective tissue diseases

1.297

1.458

1.304

Genitourinary system diseases

–

1.109

–

Symptoms and signs and abnormal clinical and laboratory findings, not elsewhere classified

–

1.059

0.959

Injury, poisoning, and certain other consequences of external causes

1.184

1.124

1.142

Stomatologicals, mouth preparations, medicinal dentifrices

–

–

–

Antacids, antiflatulents, and anti-ulcers

0.764

0.77

0.765

Functional gastrointestinal disorder drugs

0.887

0.764

0.892

Antiemetics and antinauseants

–

0.457

–

Bile therapy and cholagogues

–

–

0.95

Drugs for constipation

0.615

0.47

0.627

Drugs for Intestinal disorder

0.671

0.679

0.663

Digestives system drug, including enzymes

–

1.179

–

Antidiabetic drugs

–

1.033

1.025

Vitamins

–

1.049

–

Mineral supplements

0.769

0.807

0.712

Anabolics, systemic

–

–

–

Other alimentary tract and metabolism products

–

1.184

–

Antithrombotic agents

0.934

0.942

0.957

Antifibrinolytics

–

0.585

–

Anti-anemic preparations

–

1.009

0.994

Cardiac therapy

0.848

0.689

0.927

Antihypertensives

–

–

–

Diuretics

0.861

0.981

0.879

Cerebral and peripheral vasotherapeutics

–

–

–

Antivaricosis/anti-hemorrhoidal preparations

–

–

–

Other cardiovascular products

–

0.96

–

Beta-blockers

0.969

0.852

0.931

Calcium antagonists

0.996

–

0.973

Agents acting on the renin–angiotensin system

0.958

0.912

0.963

Lipid-regulating/anti-atheroma preparations

0.881

0.739

0.879

Cardiovascular multitherapy combination products

–

–

–

Antipruritic, including topical antihistamine, anaesthetic

–

–

–

Nonsteroidal product for inflammatory skin disorders

–

–

–

Other dermatological preparations

–

–

–

Gynecological anti-infective agents

–

–

–

Sex hormones and products with similar desired effects, systemic action only

–

–

–

Urologics

–

–

–

Systemic corticosteroids

–

1.148

0.978

Thyroid therapy

–

1.009

0.975

Other types of hormones

–

1.323

–

Systemic antibacterials

0.579

0.531

0.559

Systemic agents for fungal infections

–

1.129

–

Antimycobacterials

–

–

–

Antivirals for systemic use

–

–

–

Antineoplastics

–

1.247

–

Cytostatic hormone therapy

1.198

1.221

1.266

Immunostimulating agents

–

–

–

Immunosuppressants

–

1.635

–

Anti-inflammatory and anti-rheumatic agents

0.789

0.689

0.781

Muscle relaxants

–

1.034

–

Anti-gout preparations

–

1.028

–

Other drugs for musculo-skeletal system disorders

–

–

–

Anesthetics

0.331

0.228

0.269

Analgesics

0.648

0.552

0.669

Anti-epileptics

1.001

1.454

–

Anti-Parkinson’s drugs

1.397

2.524

1.408

Psycholeptics

0.763

0.878

0.735

Psychoanaleptics, excluding anti-obesity preparations

1.006

1.329

1.061

Other Central Nervous System drugs

1.138

1.28

1.174

Antiprotozoals and anthelmintics

–

–

–

Anti-asthma and COPD products

–

–

–

Cough and cold preparations

0.855

0.703

0.853

Systemic antihistamines

–

–

–

Other respiratory system products

–

–

–