Table 1 Baseline parameters in the unmatched setting.
Parameter ± SD | RAS-inhibitors (n = 41) | No RAS-inhibitors (n = 626) | P |
|---|---|---|---|
Female, n (%) | 13 (32) | 226 (36) | 0.62 |
Underlying liver disease | |||
Alcoholic cirrhosis, n (%) | 14 (34) | 284 (45) | 0.20 |
Viral hepatitis, n (%) | 9 (22) | 105 (17) | 0.69 |
Other, n (%) | 18 (44) | 221 (35) | 0.31 |
Presence of varices, n (%) | 32 (78) | 476 (76) | 0.85 |
History of variceal bleeding, n (%) (%) | 3 (7) | 85 (14) | 0.34 |
Mean arterial pressure, mmHg | 79 ± 13 | 75 ± 14 | 0.26 |
Infection at baseline, n (%) | 18 (44) | 237 (38) | 0.51 |
UTI, n (%) | 3 (7) | 45 (7) | 1.00 |
SBP, n (%) | 13 (32) | 121 (19) | 0.07 |
Other, n (%) | 2 (5) | 79 (13) | 0.21 |
Age, years | 62 ± 12 | 56 ± 11 | 0.001 |
MELD, points (time of first paracentesis) | 16 ± 7 | 19 ± 7 | 0.02 |
MELD, points (time of admission) | 16 ± 3 | 19 ± 4 | 0.001 |
ACLF at baseline, n (%) | 3 (7) | 30 (5) | 0.45 |
Creatinine, µmol/l | 125 ± 71 | 144 ± 103 | 0.23 |
eGFR, ml/min/1.73 m2 | 61 ± 23 | 51 ± 29 | 0.06 |
Bilirubin, µmol/l | 67 ± 111 | 78 ± 146 | 0.11 |
INR | 1.39 ± 0.25 | 1.55 ± 0.44 | 0.001 |
Leukocyte count, tsd/µl | 7.2 ± 3.6 | 9.0 ± 0.71 | 0.13 |
Cholinesterase, n (%) | 2.88 ± 1.32 | 2.13 ± 1.08 | 0.006 |
Sodium, mmol/l | 137 ± 5 | 135 ± 5 | 0.02 |
ALT, IU/ml | 35 ± 19 | 48 ± 69 | 0.36 |
Albumin, g/l | 27 ± 6 | 26 ± 6 | 0.51 |
Diabetes mellitus, n (%) | 19 (46) | 144 (23) | 0.002 |
Platelet count, tsd/µl | 166 ± 142 | 139 ± 97 | 0.11 |
History of SBP, n (%) | 14 (34) | 127 (20) | 0.03 |
Diuretics, n (%) | 31 (76) | 446 (71) | 0.60 |
Presence of refractory ascites, n (%) | 4 (9) | 67 (11) | 0.85 |
HCC, n (%) | 2 (5) | 31 (5) | 0.13 |
NSBB, n (%) | 18 (44) | 196 (31) | 0.12 |
