Figure 1
From: Bifurcation analysis of a tuberculosis progression model for drug target identification
Mathematical model of the immunopathological progression of TB. (A) Graphical representation of the key mechanisms that describe the regulatory interplay between macrophages and bacteria. Dotted lines represent phase-dependent rates. (B) Historic bacteria population triggers phase changes when the threshold values KM1 and KM2 are surpassed at critical times 1 and 2. (C) Phase changes are reflected by adaptations in the values of the model parameters described in Table 2, which can transiently increase (top), stepwise increase (middle) or stepwise decrease (bottom). (D) The mathematical model with nominal parameters taken from17 reproduces the validation data set extracted from48, corresponding to BALBc mice challenged intratracheally with 2.5 × 105 CFU of H37Rv bacteria.
