Figure 6
(A) Box plots of the length distributions of myelin sheaths with > 80% of wrapped circumference at the concentration corresponding to the maximum wrapping index for each compound. (B) Normalized histograms showing differences in the length distribution of myelin sheaths > 6 µm, for tasin-1, T3, and clobetasol. Histograms were generated for concentrations corresponding to the maximum wrapping index (111 nM for tasin-1 and T3, and 3 μM for clobetasol). (C) Box plots showing the length distribution of myelin sheaths with > 80% of wrapped circumference for tasin-1 and benztropine at different drug concentrations. Box represents the interquartile range of 25 (Q1)-75 (Q3) percentile (IQR), whiskers represent data set minimum (Q1-1.5*IQR) and maximum (Q3 + 1.5*IQR), diamonds represent individual outliers, middle line represents data set median. (D) Comparison of maximum wrapping index for myelin sheath length > 6 µm (red) and > 10 µm (violet). Error bars are standard error of the mean (SEM) (for 3 replicates with combined n = 27 fields of view).
