Figure 5
CEP20 knockdown promotes high expression of microtubule bundle formation and cell adhesion related genes. (A) Volcano plot showing the differentially expressed genes in siCEP20 vs siCTR samples. Red dots: upregulated genes in siCEP20 samples, blue dots: downregulated genes in siCEP20 samples. (B, C) Bubble plots of GO terms enriched in up- and downregulated genes in in siCEP20 samples. Point sizes represent the gene numbers in each term, orange and blue gradients represent the − log10 (adjusted P values). (D) Expression heatmap of microtubule bundle formation related genes in siCTR and siCEP20 samples. (E) GSEA of adherens junction, gap junction and tight junction pathways in siCEP20 versus the siCTR samples.
