Figure 4
Functional response with signal feedback. Dots, functional response to an agonist (EMAX = 1, RT = 1, KA = 10−6 M) in the model of the system with constant negative feedback (δ = 5) according to Eq. (19). Values of operational efficacies τ are indicated in the legend. Full lines, left, Black & Leff equation (Eq. (7)), right, Hill equation (Eq. (10)) fitted to the data. Parameter estimates are in Table 2.
