Table 1 Results of fitting Black & Leff equations to the model of non-competitive auto-inhibition. Black & Leff (Eq. (7)) and Hill (Eq. (10)) equations were fitted to model data Eq. (15) with EMAX fixed to 1 or E’MAX confined < = 1, respectively.
Black & Leff | Hill | Equation 18 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
τ | pKA | KI | τ’ | n | τ | τn | pKA | E’MAX | nH | pEC50 | E’MAX | τ | pKA | pKA |
0.2 | 6.00 | 1 | 0.091 | 1.33 | 0.166 | 0.0917 | 5.91 | 0.084 | 1.21 | 5.78 | 0.083 | 0.090 | 5.74 | 5.99 |
0.5 | 6.00 | 1 | 0.200 | 1.46 | 0.333 | 0.201 | 5.98 | 0.167 | 1.22 | 5.84 | 0.165 | 0.199 | 5.76 | 5.99 |
1 | 6.00 | 1 | 0.333 | 1.58 | 0.499 | 0.333 | 6.06 | 0.250 | 1.22 | 5.91 | 0.248 | 0.330 | 5.79 | 5.99 |
2 | 6.00 | 1 | 0.500 | 1.71 | 0.666 | 0.499 | 6.15 | 0.333 | 1.21 | 5.99 | 0.331 | 0.494 | 5.82 | 6.00 |
5 | 6.00 | 1 | 0.714 | 1.55 | 0.804 | 0.713 | 6.15 | 0.416 | 1.18 | 6.10 | 0.414 | 0.706 | 5.87 | 6.00 |
