Table 3 Results of fitting Black & Leff equations to the model of the system with a similar expression of receptor and effector ([RT]≈[GT]). Black & Leff (Eq. (7)) and Hill (Eq. (10)) equations were fitted to model data with EMAX fixed to 1 or E’MAX confined < = 1, respectively.
Black & Leff | Hill | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
τ | pKA | n | τ | τn | pKA | E’MAX | nH | pEC50 | E’MAX | τ | pKA |
1000 | 7.00 | 1.91 | 6701 | 2.03.107 | 4.50 | 1.00 | 1.89 | 8.32 | 1.00 | CNBD | CNBD |
100 | 7.00 | 1.54 | 36.2 | 251 | 6.68 | 0.996 | 1.52 | 8.23 | 0.991 | 108 | 6.19 |
33.3 | 7.00 | 1.35 | 13.6 | 33.9 | 6.98 | 0.971 | 1.29 | 8.10 | 0.968 | 30.1 | 6.61 |
10 | 7.00 | 1.15 | 6.94 | 9.28 | 6.98 | 0.903 | 1.11 | 7.84 | 0.900 | 9.04 | 6.84 |
3.33 | 7.00 | 1.05 | 2.93 | 3.09 | 6.98 | 0.756 | 1.03 | 7.55 | 0.755 | 3.08 | 6.94 |
