Table 2 Associations between immunohistochemical markers of angiogenesis and quantitative mpMRI-parameters.

From: Microvascular proliferation is associated with high tumour blood flow by mpMRI and disease progression in primary prostate cancer

Variables

MVD1

pMVD1

VPI1

GMP2

Low

High

p-value3

Low

High

p-value3

Low

High

p-value3

Absent

Present

p-value3

n (%)

n( %)

 

n (%)

n (%)

 

n (%)

n (%)

 

n (%)

n (%)

 

Ktrans4

  

0.3

  

0.43

  

1

  

0.47

Low

17 (57)

13 (43)

 

13 (43)

17 (57)

 

14 (47)

16 (53)

 

27 (90)

3 (10)

 

High

13 (43)

17 (57)

 

10 (33)

20 (67)

 

14 (47)

16 (53)

 

24 (80)

6 (20)

 

kep4

  

0.61

  

0.063

  

0.12

  

0.15

Low

16 (53)

14 (47)

 

15 (50)

15 (50)

 

17 (57)

13 (43)

 

28 (93)

2 (7)

 

High

14 (47)

16 (53)

 

8 (27)

22 (73)

 

11 (37)

19 (63)

 

23 (77)

7 (23)

 

ve4

  

0.3

  

0.43

  

0.038

  

1

Low

17 (57)

13 (43)

 

10 (33)

20 (67)

 

10 (33)

20 (67)

 

26 (87)

4 (13)

 

High

13 (43)

17 (57)

 

13 (43)

17 (57)

 

18 (60)

12 (40)

 

25 (83)

5 (17)

 

Blood flow5

  

0.42

  

0.008

  

0.054

  

0.32

Low

8 (62)

5 (38)

 

9 (69)

4 (31)

 

9 (69)

4 (31)

 

13 (100)

0 (0)

 

High

19 (49)

20 (51)

 

10 (26)

29 (74)

 

15 (39)

24 (61)

 

33 (85)

6 (15)

 

ADC4

  

0.18

  

0.032

  

0.038

  

0.51

High

14 (41)

20 (59)

 

18 (53)

16 (47)

 

21 (62)

13 (38)

 

27 (82)

6 (18)

 

Low

19 (58)

14 (42)

 

9 (27)

24 (73)

 

12 (36)

21 (64)

 

30 (88)

4 (12)

 
  1. 1Microvessel density/mm2, proliferating microvessel density/mm2 and vascular proliferation index (%) in pathological high-grade area, dichotomised by median.
  2. 2Glomeruloid microvascular proliferation.
  3. 3P-value, Pearson Chi-square or Fisher`s Exact Test.
  4. 4Median value of Ktrans (min-1), median value of kep (min-1), median value of ve and apparent diffusion coefficient (mm2/s) in pathological high-grade area, dichotomised by median.
  5. 5Mean value of blood flow (mL/100 g/min) in pathological high-grade area, dichotomised by lower quartile.