Figure 5
From: Acamprosate reduces ethanol intake in the rat by a combined action of different drug components
Calcium chloride combined with sodium acamprosate produce a prolonged reduction of ethanol intake. Systemic injection (i.p.) of CaCl2 (73.5 mg/kg; n = 14) as well as CaCl2 + NaAcamp (73.5 mg/kg + 200 mg/kg; n = 14) significantly decreased ethanol intake (g/kg/6 h) during the first two treatment sessions, as compared to vehicle treated controls (n = 15; A), while a prolonged reduction in ethanol intake was induced solely by CaCl2 + NaAcamp (A). Water intake (g/kg/6 h) (B) and ethanol preference (% EtOH of total consumption) (C) demonstrated a significant escalation and reduction, respectively, throughout the treatment sessions, as compared with vehicle controls. # denotes CaCl2 significant compared to vehicle and * denotes CaCl2 + NaAcamp significant compared to vehicle. All data are presented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001. CaCl2 calcium chloride, EtOH ethanol, NaAcamp sodium acamprosate.
