Table 4 Proteins identified to be released in greater abundance from DEG compared to PRES by a quantitative proteomic analysis.
From: Analysis of proteins released from osteoarthritic cartilage by compressive loading
Rank | Accession | Description | Coverage (%) | Peptides | Abundance | Relative ratio | |||
|---|---|---|---|---|---|---|---|---|---|
CONT1 | CONT2 | DEG1 | DEG2 | ||||||
No. 1 | O43707 | Alpha-actinin-4 | 2.4 | 2 | 195,900 | 330,600 | 2,080,000 | 2,967,000 | 9.586 |
No. 2 | P49747 | Cartilage oligomeric matrix protein | 71.5 | 46 | 344,900,000 | 283,800,000 | 2.543E + 09 | 1.501E + 09 | 6.432 |
No. 3 | P02751 | Fibronectin | 44.0 | 81 | 268,600,000 | 316,100,000 | 1.423E + 09 | 2.263E + 09 | 6.304 |
No. 4 | P51884 | Lumican | 49.7 | 16 | 100,900,000 | 104,300,000 | 966,900,000 | 290,600,000 | 6.128 |
No. 5 | P02679 | Fibrinogen gamma chain | 40.0 | 22 | 128,000,000 | 104,800,000 | 553,200,000 | 485,000,000 | 4.460 |
No. 6 | Q06828 | Fibromodulin | 35.4 | 11 | 28,720,000 | 33,490,000 | 189,500,000 | 73,550,000 | 4.228 |
No. 7 | Q92765 | Secreted frizzled-related protein 3 | 4.0 | 1 | 9251 | 23,670 | 26,780 | 109,000 | 4.124 |
No. 8 | P61626 | Lysozyme C | 72.3 | 12 | 45,410,000 | 75,130,000 | 318,800,000 | 176,200,000 | 4.107 |
No. 9 | P02675 | Fibrinogen beta chain | 56.8 | 27 | 172,800,000 | 119,700,000 | 638,700,000 | 547,300,000 | 4.055 |
No.10 | P02458 | Collagen alpha-1(II) chain | 18.0 | 26 | 46,540,000 | 57,630,000 | 345,200,000 | 67,440,000 | 3.961 |
No.11 | Q99983 | Osteomodulin | 15.0 | 6 | 4,747,000 | 5,389,000 | 27,450,000 | 12,400,000 | 3.932 |
No.12 | Q08345 | Epithelial discoidin domain-containing receptor 1 | 1.3 | 1 | 306,900 | 942,700 | 3,428,000 | 1,288,000 | 3.774 |
No.13 | P02452 | Collagen alpha-1(I) chain | 14.6 | 18 | 8,711,000 | 14,050,000 | 58,960,000 | 22,040,000 | 3.559 |
No.14 | P21810 | Biglycan | 46.5 | 14 | 31,070,000 | 38,410,000 | 187,800,000 | 55,790,000 | 3.506 |
No.15 | O15335 | Chondroadherin | 63.5 | 19 | 38,670,000 | 48,070,000 | 225,300,000 | 65,550,000 | 3.353 |
No.16 | P02743 | Serum amyloid P-component | 35.9 | 9 | 18,130,000 | 27,550,000 | 64,140,000 | 88,800,000 | 3.348 |
No.17 | P02671 | Fibrinogen alpha chain | 41.9 | 35 | 195,800,000 | 222,300,000 | 714,000,000 | 679,100,000 | 3.332 |
No.18 | P07585 | Decorin | 46.5 | 18 | 152,700,000 | 326,600,000 | 1.177E + 09 | 407,500,000 | 3.306 |
No.19 | Q15113 | Procollagen C-endopeptidase enhancer 1 | 44.8 | 18 | 17,430,000 | 15,380,000 | 83,690,000 | 23,530,000 | 3.268 |
No.20 | P69905 | Hemoglobin subunit alpha | 62.7 | 8 | 132,100,000 | 77,270,000 | 365,000,000 | 311,000,000 | 3.229 |
