Table 5 Results of GO enrichment analysis.
From: Analysis of proteins released from osteoarthritic cartilage by compressive loading
Category | Term | Protein count | % | P value | Fold enrichment |
|---|---|---|---|---|---|
GOTERM_BP_DIRECT | GO:0030199 ~ collagen fibril organization | 10 | 16.9 | 1.40E−13 | 54.4 |
GO:0030198 ~ extracellular matrix organization | 12 | 20.3 | 2.10E−12 | 23.7 | |
GO:0001501 ~ skeletal system development | 11 | 18.6 | 8.64E−12 | 26.4 | |
GO:0072378 ~ blood coagulation, fibrin clot formation | 4 | 6.8 | 9.00E−07 | 186.5 | |
GO:0070527 ~ platelet aggregation | 5 | 8.5 | 1.01E−05 | 36.3 | |
GO:0007160 ~ cell–matrix adhesion | 6 | 10.2 | 1.75E−05 | 18.3 | |
GO:0007155 ~ cell adhesion | 9 | 15.3 | 2.50E−04 | 5.3 | |
GO:0090277 ~ positive regulation of peptide hormone secretion | 3 | 5.1 | 3.95E−04 | 97.9 | |
GO:0045087 ~ innate immune response | 9 | 15.3 | 3.98E−04 | 4.9 | |
GO:0007601 ~ visual perception | 6 | 10.2 | 4.31E−04 | 9.3 | |
GOTERM_MF_DIRECT | GO:0005201 ~ extracellular matrix structural constituent | 22 | 37.3 | 2.07E−31 | 53.6 |
GO:0005518 ~ collagen binding | 11 | 18.6 | 4.96E−15 | 54.3 | |
GO:0008201 ~ heparin binding | 12 | 20.3 | 2.94E−12 | 22.9 | |
GO:0030021 ~ extracellular matrix structural constituent conferring compression resistance | 7 | 11.9 | 3.69E−12 | 147.0 | |
GO:0050840 ~ extracellular matrix binding | 6 | 10.2 | 2.84E−08 | 65.0 | |
GO:0030020 ~ extracellular matrix structural constituent conferring tensile strength | 6 | 10.2 | 1.23E−07 | 49.2 | |
GO:0048407 ~ platelet-derived growth factor binding | 4 | 6.8 | 3.84E−06 | 122.1 | |
GO:0002020 ~ protease binding | 6 | 10.2 | 1.65E−05 | 18.5 | |
GO:0005178 ~ integrin binding | 6 | 10.2 | 1.06E−04 | 12.5 | |
GO:0016504 ~ peptidase activator activity | 3 | 5.1 | 4.54E−04 | 91.6 | |
GOTERM_CC_DIRECT | GO:0005615 ~ extracellular space | 44 | 74.6 | 4.09E−32 | 7.9 |
GO:0005576 ~ extracellular region | 40 | 67.8 | 3.96E−25 | 6.5 | |
GO:0031012 ~ extracellular matrix | 20 | 33.9 | 2.67E−22 | 26.8 | |
GO:0070062 ~ extracellular exosome | 29 | 49.2 | 8.94E−13 | 4.5 | |
GO:0005788 ~ endoplasmic reticulum lumen | 12 | 20.3 | 8.48E−10 | 13.6 | |
GO:0005581 ~ collagen trimer | 8 | 13.6 | 7.32E−09 | 30.2 | |
GO:0072562 ~ blood microparticle | 9 | 15.3 | 7.41E−09 | 21.5 | |
GO:0005796 ~ Golgi lumen | 8 | 13.6 | 1.98E−08 | 26.2 | |
GO:0043202 ~ lysosomal lumen | 7 | 11.9 | 3.02E−07 | 25.3 | |
GO:0005577 ~ fibrinogen complex | 4 | 6.8 | 1.20E−06 | 173.5 |
