Table 2 Logistic regression analysis for prediction of lymph node metastasis risk.

From: Loss of CDH16 expression is a strong independent predictor for lymph node metastasis in Middle Eastern papillary thyroid cancer

Risk factor

Univariate analysis

Multivariate analysis

OR (95% CI)

P value

OR (95% CI)

P value

Age (> 55 years)

0.90 (0.69–1.18)

0.4439

  

Male sex

1.41 (1.11–1.80)

0.0055

1.21 (0.92–1.59)

0.1805

Aggressive Histotypes

1.12 (0.86–1.46)

0.3982

  

Bilateral tumors

2.11 (1.68–2.64)

< 0.0001

1.74 (1.23–2.45)

0.0016

Multifocal tumors

1.71 (1.39–2.10)

< 0.0001

0.99 (0.72–1.36)

0.9406

Extrathyroidal extension

3.91 (3.13–4.89)

< 0.0001

3.11 (2.43–3.96)

< 0.0001

Lymphovascular invasion

1.86 (1.46–2.39)

< 0.0001

1.33 (0.99–1.78)

0.0502

T status (T3/4 vs T1/2)

1.62 (1.27–2.06)

< 0.0001

1.14 (0.87–1.49)

0.3338

Distant metastasis

2.44 (1.45–4.13)

0.0008

1.39 (0.79–2.45)

0.2542

CDH16 negative

2.94 (2.01–4.31)

< 0.0001

2.46 (1.60–3.79)

< 0.0001

  1. OR odds ratio, CI confidence interval.
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