Figure 5

Interaction between the effect of lesion location with distance, size, and conductivity on E-field magnitude in M1. (A) Differences in E-field magnitude in M1 grey matter (GM) compared to non-lesioned brain plotted against lesion location, split by lesion distance (in mm). Data are the results from individual simulations of each lesion state. Lesions located in-line with the predominant orientation of current flow in M1 increased E-field magnitude, whereas those in the opposite direction caused a decrease. This was modulated by lesion distance, where closer lesions to the ROI had a greater impact on E-field magnitude. Lesion states from P03–P05 are shown in red. (B) Same as A but split by lesion size (radius in mm), demonstrating that larger lesions have a greater impact on E-field magnitude. (C) Differences in E-field magnitude plotted against lesion location, split by conductivity (in S/m), showing that lesions with higher conductivity have a greater effect on E-field magnitude. Lesion states from P03–P05 are shown in black.