Figure 6

Interaction between the effect of lesion location with distance, size, and conductivity on E-field magnitude in BA44. (A) Differences in E-field magnitude in BA44 grey matter (GM) compared to non-lesioned brain plotted against lesion location, split by lesion distance (in mm). Data are the results from individual simulations of each lesion state. Lesions located in-line with the predominant orientation of current flow in BA44 increased E-field magnitude, whereas those in the opposite direction caused a decrease. This was modulated by lesion distance, where closer lesions to the ROI had a greater impact on E-field magnitude. (B) Same as (A) but split by lesion size (radius in mm), demonstrating that larger lesions have a greater impact on E-field magnitude. (C) Differences in E-field magnitude plotted against lesion location, split by conductivity (in S/m), showing that lesions with higher conductivity have a greater effect on E-field magnitude.