Table 2 Various dermatokinetic parameters (Mean ± SD) of ETO topical formulations in epidermis and dermis.
Parameters | Conventional gel formulation (Mean ± SD) | DE-gel formulation (Mean ± SD) | ||
|---|---|---|---|---|
Epidermis | Dermis | Epidermis | Dermis | |
AUC0-12 h (µg/cm2) | 623.13 ± 9.3 | 365.41 ± 18.1 | 1758.17 ± 42.9 | 1206.11 ± 89 |
\({C}_{max}^{Skin}\)(µg/cm2) | 96.64 ± 1.61 | 48.54 ± 2.1 | 275.66 ± 13.12 | 138.25 ± 10.11 |
\({T}_{max}^{Skin}\)(h) | 4.2 ± 0.34 | 6.1 ± 0.26 | 3.6 ± 0.39 | 4.8 ± 0.41 |
Kp (h−1) | 0.42 ± 0.06 | 0.32 ± 0.04 | 0.61 ± 0.09 | 0.45 ± 0.11 |
