Figure 10
From: Morphine aggravates inflammatory, behavioral, and hippocampal structural deficits in septic rats
Effect of morphine (7 mg/kg, s.c.) on (A) normal neurons, (B) degenerated neurons, (C) glial cells in CA1 region of hippocampus of sham and septic rats. Representative photomicrographs of the rat hippocampus (CA1, HE, × 400) are shown. Data are means ± S.E.M. of observations. Normal neurons (black arrow), misaligned degenerated, shrunken neurons with pyknotic and hyperchromatic nuclei (red arrow) necrotic pyramidal with satellitosis and neuronophagia (green arrow). Data were expressed as mean ± S.E.M. One-way ANOVA followed by the Tukey’s post hoc test was used to measure statistical significance. *P < 0.05 vs. Sham-saline, +P < 0.05 vs. CLP-saline, #P < 0.05 vs. Sham-morphine.
