Figure 1

Intracellular cAMP levels in HC (n = 3) and SSc (n = 3) dermal fibroblasts in the presence or absence of 1–10 μM apremilast. The 10 μM forskolin served as a positive control. The data were expressed as the mean ± SD per group. *p < 0.05. cAMP, cyclic Adenosine 5'-Monophosphate; HC, healthy control; SD, standard deviation; SSc, systemic sclerosis.