Figure 2 | Scientific Reports

Figure 2

From: High specificity THz metamaterial-based biosensor for label-free transcription factor detection in melanoma diagnostics

Figure 2

Exemplary frequency response for one measurement spot being sequentially functionalized with a biofilm here shown in logarithmic scale. Yellow plot: Clean sensor surface with exposed gold in undercut-etch area. Green plot: dsDNA was immobilized in the undercut-etch area of this query field, filling the gaps in the dsDNA biofilm with mercaptohexanol (MCH), thereby covering up the remaining exposed gold surface effectively. The term capture DNA refers to the capability of the present DNA film to selectively bind EGR2 transcription factors. Blue plot: In the measured spot, the sensor was treated with a solution from nucleus proteins extracted from human malignant melanoma cells. The translucent bands around the solid curves indicate the standard deviation \(\sigma _{(N\,=\,5)}\) of each measurement stage. The inset illustrates how the resonance frequency shift \(\Delta f_\text{R}\) is evaluated.

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