Figure 2 | Scientific Reports

Figure 2

From: Human leukocyte antigen-DQ risk heterodimeric haplotypes of left ventricular dysfunction in cardiac sarcoidosis: an autoimmune view of its role

Figure 2

Heatmaps by the minimum IC50 profile among 68 patients with CS. The minimum IC50 profiles for the HLA-DQ locus among 68 patients with CS were expressed as a heatmap (IC50 value above 50 nM were displayed in blue, and IC50 values below 50 nM were displayed in two levels of threshold: dark red for IC50 value below 12.5 nM, and gradational change from red to white for IC50 value above 12.5 nM up to 50 nM) and rearranged in the following manner- (a) The profiles were rearranged by hierarchical clustering of affinity profile. The vertical axis is the 172 target proteins to be analysed, grouped by each category. Group-1 to -7 indicate the categories of proteins in Fig. 4. The part surrounded by a square (10 cases) indicates the group with a particularly high BA compared to others. (b) The profiles were rearranged in the order of LVEF. The vertical axis is same as Fig. 3a. Cases highlighted by an arrowhead indicate individuals of the group with a particularly high BA in Fig. 3a. The green triangles indicate the borderline of 50% in LVEF.

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