Figure 3 | Scientific Reports

Figure 3

From: Human leukocyte antigen-DQ risk heterodimeric haplotypes of left ventricular dysfunction in cardiac sarcoidosis: an autoimmune view of its role

Figure 3

Characteristics of HLA-II heterodimeric haplotypes and proteins with strong binding affinity. (a) Heatmap consisting of proteins with strong (IC50 < 12.5 nM) BA only at HLA-DQ locus (for 68 patients with CS). The horizontal axis shows the patients with CS arranged in the order of LVEF. The cases highlighted by arrowheads indicate individuals of the group with a particularly high BA in Fig. 2a. These cases harboured the haplotypes DQA1*05:0X/DQB1*03:01. Group-1 to -4 indicate the categories of proteins from Fig. 4. The green triangles indicate the borderline of 50% in LVEF. (b) Epitopes with especially strong binding affinities for HLA-DQA1*05:0X/DQB1*03:01 in each protein. The column labelled “Core” indicates the core binding region in each epitope, which is the nine amino acid sequence corresponding to pocket-1 to -9 of the epitope-binding domain. (c) The homology of amino acid sequences in anchor pockets of HLA-DQA1*05:0X.

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