Table 3 Association analysis for the risk HLA-DQ haplotypes of CS incidence.

From: Human leukocyte antigen-DQ risk heterodimeric haplotypes of left ventricular dysfunction in cardiac sarcoidosis: an autoimmune view of its role

Haplotype

Cardiac sarcoidosis (n = 68)

Control (n = 311)

P_adj

DQA1*03:03/DQB1*06:01

16 (23%)

13 (4.2%)

1.5E-04 *

DQA1*01:03/DQB1*04:01

12 (17%)

9 (2.9%)

2.3E-03 *

DQA1*01:03/DQB1*06:01

38 (55%)

105 (34%)

n.s

DQA1*01:01/DQB1*05:01

1 (1.5%)

28 (9.0%)

n.s

DQA1*03:02/DQB1*06:01

10 (14%)

21 (6.8%)

n.s

DQA1*05:05/DQB1*06:02

2 (2.9%)

1 (0.3%)

n.s

DQA1*01:03/DQB1*03:03

10 (14%)

24 (7.7%)

n.s

DQA1*03:03/DQB1*03:02

4 (5.9%)

7 (2.3%)

n.s

DQA1*03:03/DQB1*04:01

21 (31%)

68 (22%)

n.s

DQA1*01:03/DQB1*03:01

5 (7.4%)

11 (3.5%)

n.s

  1. A total of 67 HLA-DQ haplotypes detected in the group with patients suffering from CS, ordered by P values; the results of the top 10 haplotypes are shown.
  2. n.s. no significant difference.
  3. *Significance after the correction for multiple testing (Bonferroni correction); P_adj. < 0.05.
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