Table 7 Association analysis between the HLA-DQ haplotype, DQA1*05:0X/DQB1*03:01, and clinical phenotypes.

From: Human leukocyte antigen-DQ risk heterodimeric haplotypes of left ventricular dysfunction in cardiac sarcoidosis: an autoimmune view of its role

 

With DQA1*05:0X/DQB1*03:01 (n = 10)

Without DQA1*05:0X/DQB1*03:01 (n = 58)

P

Clinical characteristics

 Age of onset (years)

61 [56–66]

62 [53–70]

0.75

 Gender (female)

6 (60%)

37 (64%)

1.00

Clinical phenotypes

 CAVB

4 (40%)

26 (45%)

1.00

 VT or VF

4 (40%)

21 (36%)

1.00

 Sustained VT or VF

2 (20%)

15 (26%)

1.00

 LVEF (%)

40 [29–46]

47 [36–60]

0.099

 Low LVEF

9 (90%)

32 (55%)

0.043 *

 Cardiac device implantation

9 (90%)

40 (69%)

0.26

 Successful corticosteroid therapy

1 (11%)

20 (43%)

0.13

  1. CAVB complete atrioventricular block, VT ventricular tachycardia, VF ventricular fibrillation, LVEF left ventricular ejection fraction, Low LVEF the patients with LVEF < 50% in the echocardiography at the enrolment.
  2. *p < 0.05.
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