Figure 6

Increased circulating progranulin does not affect atrial expression levels of pro-inflammatory genes. RNA was isolated from the atria of all groups at 20 weeks and expression levels of pro-inflammatory genes evaluated by qPCR. No significant changes in expression levels of Il1b, Il6, Il18, Tnf, or Nlrp3 were observed (a–e). n = 6 for all groups. p > 0.05 for all comparisons. Data are presented as individual values, bars represent mean ± SD.